With the help of HUN-REN’s grant, special technology is used to describe large-coverage interaction maps and adaptation landscapes that determine the progression of cancer.
Gábor Boross, as part of the HUN-REN Hungarian Research Network’s Calling Home program, is joining the HUN-REN Ecological Research Center (ÖK) from Stanford University, where he is founding a new research group to research the evolution of cancer.
The specialist returns home from the United States of America, where he researched the evolution of lung cancer in mice as a postdoctoral researcher at Stanford University. In the HUN-REN ÖK Institute of Evolutionary Sciences, with the new research group that he will establish, he will investigate how the so-called “driver” mutations that cause cancer interact to eventually cause the growth of cancerous tumors.
According to the announcement, Gábor Boross used the Tuba-seq technology developed there at Stanford University. The essence of this is that using the CRISPR genome engineering technique, specific mutations are created in mouse lung epithelial cells, and the tumors that start to grow from them are marked with so-called DNA barcodes. By sequencing these short DNA segments, the size of tumors can be determined, thereby determining how specific mutations affect the growth of tumors, or even how they influence the response to various therapies.
As cancerous growth is almost invariably caused by multiple mutations in human tumors, the young researcher further developed the Tuba-seq technology during his research work in the United States. The purpose of this was to make the system suitable for handling combinations of mutations in a highly scalable way, i.e. with few experiments, many mutants could be measured cheaply. He is now bringing this technology home with the help of the HUN-REN grant and using it to describe large-coverage interaction maps and adaptation landscapes that determine the progression of cancer.
According to the information, six Hungarian and one foreign researcher belonging to the international vanguard will come to Hungary to form a research group within the network and to implement the scientific project undertaken in the winning application in the program for inviting and recruiting foreign researchers announced for the first time in 2023 by HUN-REN.